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Bone defects, especially large ones, still present a significant challenge in orthopedic tissue engineering, due to the limited self-repair capacity of bone tissues...
Development of a Novel Method for the Strengthening and Toughening of Irradiation-Sterilized Bone Allografts used in Orthopaedic Reconstructions
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Over 900,000 bone-grafting procedures are performed each year in the USA 1 . Human bone allografts are used in the orthopaedic reconstruction of skeletal defects resulting from traumatic injuries, diseases and revision arthroplasty however, bone allografts have insufficient mechanical properties 2 and graft fracture is a documented clinical failure mode 3 ...
Total joint arthroplasty TJA is the most common treatment option for severe arthritis. Typically the bearing design is a metal CoCr component on an ultra-high molecular weight polyethylene UHMWPE counterface...
Tissue engineering is an advancing field due in part to the development of polymers in geometries and dimensions similar to those found in the native extracellular matrix...
Articular cartilage has a limited capacity for regeneration. Tissue engineering aims to generate functional cartilage tissue to replace the damaged tissue...