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The transcription factor Ascl1 plays a key role in neural development. Recently Ascl1 was identified as a pioneer factor capable of reprogramming other cell types of the central nervous system into neurons using viral mediated overexpression1...
Lipid-modified low molecular weight polyethyleneimines LMW PEIs are promising non-viral gene delivery systems that have been successfully explored for the treatment of various diseases through the delivery of plasmid DNA pDNA or mRNA to expression therapeutic proteins thereby restoring the defective protein, for the knockdown of aberrant proteins using RNA interference RNAi with short interfering RNA siRNA or for the complete knockout of the gene using CRISPR technology 1, 2 ...
Bisphosphonates are calcium-binding drugs that inhibit the bone-resorbing function of osteoclasts1. Nitrogen-containing bisphosphonates target farnesyl diphosphate synthase, an enzyme of the mevalonate pathway...
Alginate-Gelatin-Matrigel Hydrogels Enable the Development and Multigenerational Passaging of Patient-Derived 3D Bioprinted Cancer Spheroid Models
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Hydrogels consisting of controlled fractions of alginate, gelatin, and Matrigel enable the development of patient-derived bioprinted tissue models that support cancer spheroid growth and expansion...
Tenure Track Biomedical Engineering Faculty Openings (two) at the University of Waterloo more
Recent Member Projects
Norma Alicia Garza Flores: Long-term hydrophilic and anti-thrombogenic dynamic covalent silicone-based biomaterials more
Norma Alicia Garza Flores: 3D printing of anti-fouling implants based on alginate-zwitterionic interpenetrating network hydrogel bioinks more
Maud Viallon: Multifunctional hydrogels for dental applications more
Balaji Ramachandran: Culturing pancreatic islets or stem cell-derived islets in FEP bags more
Recent Member Publications
Khaled Hijazi: Titanium Alloy Implants with Lattice Structures for Mandibular Reconstruction more
Christina Boghdady: Ultrasoft edge-labelled hydrogel sensors reveal internal tissue stress patterns in invasive engineered tumors more
Christina Boghdady: Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales more
Khaled Hijazi: Ultrastructural response of tendon to excessive level or duration of tensile load supports that collagen fibrils are mechanically continuous more