Mineralized polyplexes for gene delivery
Supervisor: Hasan Uludag
Viruses have been shown to mineralize in nature, receiving an advantage on infectivity and survival outside of a host due to material-specific bio interactions. Our goal is to explore if non-viral vectors –polyplexes, in this case – can acquire similar properties upon mineralization. This requires the study of nucleation strategies and ideal supersaturations for the achievement of a polyplex protected by a mineral shell with controlled size at the nanometric scale.
Keywords: gene therapy, calcium phosphate, calcium carbonate, poly(ethylenimine), poly(aspartic acid)
Techniques: electron microscopy (scanning and transmission), flow cytometry, DLS and ELS, among others
Teo Dick
Contact Information
- University of Alberta
Department of Chemical and Materials Engineering - 109 street ,
Edmonton, Alberta,
Canda T5K 2Y3 - Email: tadick@ualberta.ca
- Work: 5879746956
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