Multilayer Tissue Scaffolds as Barrier Membranes in Periodontal Regeneration
Supervisor: Todd Hoare
Periodontal disease is a chronic inflammatory condition affecting the tooth-supporting tissues, with severe periodontitis impacting nearly 19% of adults worldwide. Conventional barrier membranes used for periodontal regeneration are limited by rapid degradation, poor cell adhesion, bacterial contamination, and unpredictable clinical outcomes. This study aimed to fabricate and evaluate multilayer electrospun scaffolds based on zwitterionic DMAPS polymers as alternative barrier membranes. Aldehyde- and hydrazide-functionalized DMAPS were successfully electrospun into multilayer scaffolds with uniform fiber morphology and stable architecture. Scanning electron microscopy confirmed consistent fiber formation, while degradation studies demonstrated structural stability up to seven days, supporting their potential for periodontal tissue engineering applications.
Keywords: Periodontal disease, zwitterionic polymers, scaffold, barrier membrane, tissue engineering
Equipment: Syringe pumps, collectors, voltage generator.
Techniques: Electrospinning, SEM.
Alexis Larios Cervantes
Contact Information
- McMaster University
Department of Biomedical Engineering - 1280 Main street west,
Hamilton, L8S 4L8 - Email: lariosca@mcmaster.ca
- Membership#C263233
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