Canadian Biomaterials Society
Société Canadienne des Biomatériaux

Ex vivo gene therapy and tissue engineering for the treatment of RDEB

Supervisor: Lucie Germain

We aim to close chronical skin wounds of recessive dystrophic epidermolysis bullosa patients using a combination of tissue engineering, relying on the use of the self-assembly approach developped at the LOEX, with retroviral gene therapy to correct for the expression of type VII collagen and therefore, restore a normal skin phenotype after graft.

Keywords: Skin, Gene therapy, Epidermolysis bullosa

Techniques: Immunofluorescence, Flow Cytometry, Viral transduction, Skin self assembly

Martin Barbier

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