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Bisphosphonates are calcium-binding drugs that inhibit the bone-resorbing function of osteoclasts1. Nitrogen-containing bisphosphonates target farnesyl diphosphate synthase, an enzyme of the mevalonate pathway...
Introduction Elastin-like polypeptides ELPs are a group of widely used synthetic polypeptides used to design stimuli responsive drug delivery systems...
Lipid-modified low molecular weight polyethyleneimines LMW PEIs are promising non-viral gene delivery systems that have been successfully explored for the treatment of various diseases through the delivery of plasmid DNA pDNA or mRNA to expression therapeutic proteins thereby restoring the defective protein, for the knockdown of aberrant proteins using RNA interference RNAi with short interfering RNA siRNA or for the complete knockout of the gene using CRISPR technology 1, 2 ...
Mg has attracted the greatest interest and so far, many biodegradable Mg alloys are developed for biomedical implant application such as Mg-Ca 1 , Mg-Mn-Zn 2 ...