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Short Aliphatic Lipid Substitution on Low Molecular Weight Polyethylenimine: Effect on siRNA Complexation from Molecular Dynamics Simulation Studies
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Post transcriptional silencing of aberrant genes with the delivery of short interfering RNA siRNA has been a potent approach to cancer therapy over the last decade...
In the area of cancer research, a major issue with conventional 2D cell culture is that it cannot reproduce complex in vivo cell-extracellular matrix ECM interactions, nor those between cancer epithelial cells and stromal compartment, which play a crucial role in tumorigenesis and progression...