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Lipid-modified low molecular weight polyethyleneimines LMW PEIs are promising non-viral gene delivery systems that have been successfully explored for the treatment of various diseases through the delivery of plasmid DNA pDNA or mRNA to expression therapeutic proteins thereby restoring the defective protein, for the knockdown of aberrant proteins using RNA interference RNAi with short interfering RNA siRNA or for the complete knockout of the gene using CRISPR technology 1, 2 ...
Polypyrrole PPy has shown considerable potential in biomedicine and energy storage owing to its inherent electrical conductivity, easy synthesis, potential of chemical modification, and biocompatibility 1,2 ...
Revascularization approaches that involve delivering growth factors with short half-lives minutes over periods of weeks in order to regenerate micro vessels have been identified as promising strategies to address disorders related to compromised tissue perfusion...
Patients with chronic kidney disease usually have a higher level of protein carbamylation than healthy people, which is strongly associated with cardiac damage, congestive heart failure, and sudden cardiac death...
Electrospun nanofibrous scaffolds are suitable for tissue engineering as their fibrous structure resembles nano micro fibre-like features of native extracellular matrix ECM , which facilitates cell attachment, growth and proliferation 1 ...